2017年筛选中心文章目录

2017年12月29日

创新药物发现专题[1]Yang Sheng-Qian, Yu Zi-Ru, Wang Lin, Yuan Tian-Yi, Wang Xue, Zhang Xue, Wang Jin-Hua, Lv Yang, Du Guan-hua*. The natural product bergenin ameliorates lipopolysaccharide-induced acute lu

创新药物发现专题

[1]

Yang Sheng-Qian, Yu Zi-Ru, Wang Lin, Yuan Tian-Yi, Wang Xue, Zhang Xue,   Wang Jin-Hua, Lv Yang, Du Guan-hua*. The natural product bergenin   ameliorates lipopolysaccharide-induced acute lung injury by inhibiting   NF-kappa B activition. J Ethnopharmacol. 2017, 200:147-155. (2016 IF 2.981)

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1

[2]

Lin Yi-Huang, Yan Yu, Zhang Hui-Fang, Chen Yu-Cai, He Yang-Yang Wang   Shou-Bao, Fang Lian-Hua*, Lu Yang, Du Guan-Hua*.   Salvianolic acid A alleviates renal injury against the systemic lupus   erythematosus induced by pristane in BALB/c mice. Acta Pharm Sin B. 2017,7(2):   159-166.

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10

[3]

杜冠华,吕扬。药品质量的影响因素——化学固体药物的晶型研究。药学研究,201736(6)311-314336

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18

[4]

杜冠华*,张莉。中药新药成药性评价关键药理学问题探讨。世界科学技术-中医药现代化,201719(3)432-438

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23

[5]

杜冠华,吕扬。仿制药一致性评价相关药物晶型的问题分析。医药导报,201736(6)593-596

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30

[6]

杜冠华,吕扬。化学药物晶型关键技术体系的建立与应用。药学进展, 201741(2)89-91

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34

[7]

杜冠华。药理学发展促进新药研发。中国药理学与毒理学杂志,201630(12)1243-1249

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37

[8]

于子茹,杜冠华*。内毒素所致急性肺损伤治疗药物研究进展。中国新药杂志,201726(13)1510-1515

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44

[9]

许律捷,姜雯,庞晓丛,康德,熊婉迪,刘睿,邢建国,刘艾林*,杜冠华。复方一枝蒿抗流感有效成分的网络药理学研究。药学学报,201752(5)745-752

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50

[10]

陈熙,杨秀颖*,方莲花,杜冠华。荧光素二乙酸酯荧光微孔法在细胞活力测定中的应用。中国医学科学院学报,201638(6)710-714

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58

 

代谢性疾病专题

[11]

Wu P, Yan Y, Ma L L, Hou B Y, He Y Y, Zhang L, Niu Z R, Song J K, Pang   X C, Yang X Y, Du G H. Effects of the Nrf2 Protein Modulator Salvianolic Acid   A Alone or Combined with Metformin on Diabetes-associated Macrovascular and   Renal Injury [J]. Journal of Biological Chemistry, 2016, 291(42): 22288-301.(2016 IF 4.125)

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63

[12]

Hou Bi-Yu, Qiang Gui-Fen, Zhao Yue-Rong, Yang Xiu-Ying, Chen Xi, Yan   Yu, Wang Xiao-Bo, Liu Chenge, Zhang Li*, Du Guan-Hua*.   Salvianolic acid A protects against diabetic nephropathy through ameliorating   glomerular endothelial dysfunction via inhibiting AGE-RAGE signaling. Cell   Physiol Biochem. 2017; 44:2378-2394.(2016 IF 5.104)

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77

[13]

Qiang Gui-Fen, Hyerim Whang Kong, Victoria Gil, Chong Wee Liew.   Transcription regulator TRIP-Br2 mediates ER stress-induced brown adipocytes   dysfunction. Sci Rep. 2017; 7: 40215. (2016 IF 4.259)

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94

肿瘤药理专题

[14]

Wang Jin-Hua, Li Wan, Zhao Ying, Kang De, Fu   Wei-Qi, Zheng Xiang-Jin, Pang Xiao-Cong, Du Guan-Hua*. Members of   FOX family could be drug targets of cancers. Pharmacol Ther. 2018, 181:   183-196. (2016 IF 11.127)

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105

[15]

Wang Jin-Hua, Hajime Hirose, Du Guan-Hua, Kelly Chong, Eiji Kiyohara,   Isaac P. Witz, Dave S.B. Hoon*. P-REX1 amplification promotes   progression of cutaneous melanoma via the PAK1/P38/MMP-2 pathway. Cancer   Lett. 2017, 407:66-75. (2016 IF 6.375)

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119

[16]

Wang Jin-hua*, Xu Ya-li, Li Li, Wang Lin, Yao Ru, Sun Qiang,   Du Guan-hua*. FOXC1 is associated with estrogen receptor alpha and   affects sensitivity of tamoxifen treatment in breast cancer. Cancer Med. 2017,   6(1): 275-287 (2016 IF 3.362)

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129

[17]

Wang Lin, Pang Xiao-Cong, Yu Zi-Ru, Yang Sheng-Qian, Liu Ai-Lin, Wang   Jin-Hua*, Du Guan-Hua*. Actinomycin D synergistically   enhances the cytotoxicity of CDDP on KB cells by activating P53 via   decreasing P53-MDM2 complex. J Asian Nat Prod Res. 2017, 19(6): 630-643.   (2016 IF 1.071)

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142

 

心脑血管药理专题

[18]

Chen Yu-Cai, Yuan Tian-Yi, Zhang Hui-Fang, Yan Yu,   Wang Dan-Shu, Fang Lian-Hua*, Lu Yang, Du Guan-Hua*.   Activation of Nrf2 attenuates pulmonary vascular remodeling via inhibiting   endothelial-to-mesenchymal transition: An insight from a plant polyphenol.   Int J Biol Sci, 2017, 13(8): 1067-1081.(2016 IF 3.873)

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171

[19]

Yuan Tian-Yi#, Chen Yu-Cai#,   Zhang Hui-Fang, Fang Lian-hua*, Du Guan-hua*.   Salvianolic acid A, a component of Salvia Miltiorrhiza, attenuates   endothelial-mesenchymal transition of HPAECs induced by hypoxia. Am J Chin   Med, 2017, 45(6): 1185-1200. (2016 IF 3.222)

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156

[20]

Yuan Tian-Yi#, Zhang Hui-Fang#, Chen Yu-Cai, Jiao   Xiao-Zhen, Xie Ping, Fang Lian-hua*, Du Guan-hua*. The   Protective Effect of DL0805 derivatives on pulmonary artery cells and the   underlying mechanisms study. Current Vasc Pharmacol. 2017, 15(5): 469-476.   (2016 IF 2.391)

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187

[21]

王丹姝,方莲花*,杜冠华*。转化生长因子β1在肺动脉高压中作用的研究进展。中国药理学通报,201733(6)741-744

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195

[22]

程笑,杨欢,杨滢霖,王月华*,杜冠华*。缺血性脑卒中后星形胶质细胞信号通路变化及潜在治疗靶点研究。中国新药杂志,201726(7)749-754

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199

[23]

张君,程笑,杨欢,杨滢霖,赵廷坤,王奇,王月华*,杜冠华*。山奈酚对慢性脑缺血大鼠学习记忆能力的影响及机制探讨。中国药理学通报,201733(1)39-44

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205

神经药理专题

[24]

Yang Huan, Cheng Xiao, Yang Ying-Lin, Wang Yue-Hua *,   Du Guan-Hua*. Ramulus Cinnamomi extract attenuates   neuroinflammatory responses via downregulating TLR4/MyD88 signaling pathway   in BV2 cells. Neural Regen Res, 2017, 12(11): 1860-1864. (2016 IF 1.769)

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211

[25]

Pang Xiao-Cong, Fu Hui, Yang Shi-Lun, Wang Lin, Liu   Ai-Lin*, Wu Song*, Du Guan-Hua*. Evaluation   of novel dual acetyl- and butyrylcholinesterase inhibitors as potential   anti-Alzheimer's disease agents using pharmacophore, 3D-QSAR, and molecular   docking approaches. Molecules. 2017, 22, 1254.(2016 IF 2.861)

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216

[26]

Zhang Xue, Du Li-Da, Zhang Wen, Yang Yu-Lin, Zhou Qi-Meng, Du Guan-Hua*.   Therapeutic effects of baicalein on rotenone-induced Parkinson's disease   through protecting mitochondrial function and biogenesis. Sci Rep. 2017,   7(1):9968. (2016 IF 4.259)

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232

[27]

Zhang Xue, Yang Yv, Du Li-Da, Zhang Wen, Du Guan-Hua*.   Baicalein exerts anti-neuroinflammatory effects to protect against   rotenone-induced brain injury in rats. Int Immunopharmacol. 2017, 50:38-47.   (2016 IF 2.956)

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246

[28]

Lian Wen-Wen, Fang Jian-Song, Xu Lv-Jie, Zhou Wei, Kang De, Xiong Wan-Di,   Jia Hao, Liu Ai-Lin*, Du Guan-Hua*. DL0410 Ameliorates   Memory and Cognitive Impairments Induced by Scopolamine via Increasing   Cholinergic Neurotransmission in Mice. Molecules. 2017, 22, 410. (2016 IF   2.861)

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256

[29]

Pang Xiao-Cong, Zhao Ying, Wang Jin-hua,   Zhou Qi-meng, Xu Lv-jie, Kang De, Liu Ai-lin*, Du Guan-hua*.   The Bioinformatic Analysis of the Dysregulated Genes and MicroRNAs in   Entorhinal Cortex, Hippocampus, and Blood for Alzheimer's Disease. Biomed Res   Int. 2017, 9084507.(2016 IF 2.476)

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270

[30]

王喆#,冯章英#,周围,庞晓丛,连雯雯,吴松,刘艾林*,杜冠华*。异黄酮衍生物J39136对东莨菪碱致学习记忆障碍模型小鼠的影响。中国新药杂志,201726(10)1110-1114

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286

药物代谢专题

[31]

Pang Xiao-Cong, Wang Lin, Kang De, Zhao Ying, Wu   Song, Liu Ai-Lin*, Du Guan-Hua*. Effects of   P-Glycoprotein on the Transport of DL0410, a Potential Multifunctional   Anti-Alzheimer Agent. Molecules. 2017, 22, 1246. (2016 IF 2.861)

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291

[32]

Yan Yu, Zhang Hui-fang, Zhang Zhi-hui, Song Jun-ke, Chen Yu-cai, Wang   Xiao-bo, He Yang-yang, Qin Hai-lin, Fang Lian-hua*, Du Guan-hua*.   Pharmacokinetics and tissue distribution of coptisine in rats after oral   administration by liquid chromatography-mass spectrometry. Biomed Chromatogr.   Biomed Chromatogr. 2017, 31(7), e3918. (2016 IF 1.613)

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303

[33]

周启蒙,宋俊科,邢逞,王金华,吕扬,杜冠华。两种晶型尼莫地平片剂在恒河猴体内药代动力学研究。药学学报,201752(12)1918-1923

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311

合作发表文章

药理学研究

[1]

Liu Wei#*, Ruiz-Velasco A#,   Wang Shou-Bao#, Khan S, Zi Min, Jungmann A, Dolores Camacho-Muñoz   M, Guo Jing, Du Guan-Hua, Xie Li-Ping, Oceandy D, Nicolaou A, Galli G, Müller   OJ, Cartwright EJ, Ji Yong*, Wang Xin*. Metabolic   stress-induced cardiomyopathy is caused by mitochondrial dysfunction due to   attenuated Erk5 signaling. Nat Commun. 2017, 8(1):494-509. (2016 IF 12.124)

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317

[2]

Yi Jie, Gao Ran, Chen Yu, Yang Zhuo, Han Pei, Zhang   Hui, Dou Ya-ling, Liu Wen-jing, Wang Wen-gong, Du Guan-hua, Xu Ying-chun*,   Wang Jin-hua*. Overexpression of NSUN2 by DNA hypomethylation is   associated with metastatic progression in human breast cancer. Oncotarget,2017,   8(13): 20751-20765.(2016 IF 5.166)

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333

[3]

Wei Can-Jing, Xu Fang, Shi Meng-Jiao, Hu Jia-Wen,   Wang Jia-Jia, Zhen Bo, Wang Xue, Ji Teng-Fei*, Wang Jin-Hua*,   Du Guan-Hua*. Synthesis and antitumor activities of sinomenine   derivatives on rings A and C. J Asian Nat Prod Res. 2017, 1:1-15.(2016 IF 1.071)

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348

[4]

Qi W, Keenan HA, Li Q, Ishikado A, Kannt A, Sadowski T, Yorek MA, Wu IH,   Lockhart S, Coppey LJ, Pfenninger A, Liew CW, Qiang Gui-Fen, Burkart AM,   Hastings S, Pober D, Cahill C, Niewczas MA, Israelsen WJ, Tinsley L, Stillman   IE, Amenta PS, Feener EP, Vander Heiden MG, Stanton RC, King GL. Pyruvate   kinase M2 activation may protect against the progression of diabetic   glomerular pathology and mitochondrial dysfunction. Nat Med. 2017, 23(6):753-762.(2016 IF 29.886)

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363

[5]

Yao Yang-Yang#, Li Ren-Ze#, Liu Xiao-Yu, Yang   Fei-Long, Yang Ying, Li Xiao-Yu, Shi Xiang, Yuan Tian-Yi, Fang Lian-Hua, Du   Guan-Hua, Jiao Xiao-Zhen*, Xie Ping*. Discovery of   Novel N-Substituted Prolinamido Indazoles as Potent Rho Kinase Inhibitors and   Vasorelaxation Agents. Molecules. 2017, 22, 1766.(2016 IF 2.861)

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376

[6]

Wang Xue, Yang Qiao-Li, Shi Yu-Zhu, Hou Bi-Yu, Yang Sheng-Qian, Huang Hua*,   Zhang Li*, Du Guan-Hua*. Protective effects of the   ethanol extract of Viola tianshanica Maxim against acute lung injury induced   by lipopolysaccharides in mice. J Microbiol Biotechnol. 2017, 27(9):1628-1638.   (2016 IF 1.75)

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392

[7]

Duan Dan-Dan, Wang Ke-Xin, Zhou Yu-Zhi, Qin Xue-Mei*, Gao Li*,   Du Guan-Hua. Baicalein exerts beneficial effects in D-galactose induced aging   rats through attenuation of inflammation and metabolic dysfunction.   Rejuvenation Res. 2017, 20(6): 506-516.(2016 IF 2.827)

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403

[8]

Fang Jian-Song, Wang Ling, Li Ye-Cheng, Lian Wen-Wen, Pang Xiao-Cong,   Wang Hong, Yuan Dong-Sheng, Wang Qi*, Liu Ai-Lin*, Du   Guan-Hua*. AlzhCPI: A knowledge base for predicting   chemical-protein interactions towards Alzheimer's disease. PLoS One. 2017,   12(5): e0178347.(2016 IF 2.806)

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414

[9]

Sun Wen, Wu Xia-Xia, Gao Hong-wei, Yu Jie, Zhao Wen-Wen, Lu Jin-Jian,   Wang Jin-hua, Du Guan-hua, Chen Xiu-Ping.    Cytosolic calcium mediates RIP1/RIP3 complex-dependent necroptosis   through JNK activation and mitochondrial ROS production in human colon cancer   cells. Free Radic Biol Med. 2017, 108: 433-444. (2016 IF 5.606)

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430

[10]

He Zi-Ning#, Lian Wen-Wen#, Liu Jia-Wei*,   Zheng Run-Sheng, Xu Hui, Du Guan-Hua, Liu Ai-Lin*. Isolation,   structural characterization and neuraminidase inhibitory activities of   polyphenolic constituents from Flos caryophylli. Phytochem Lett, 2017, 19:   160-167.(2016 IF 1.418)

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442

[11]

Zhou Yu-Zhi, Li Xiao, Gong Wen-Xia, Tian Jun-Sheng, Gao Xiao-Xia, Gao Li,   Zhang Xiang, Du Guan-Hua, Qin Xue-Mei*. Protective effect of   isoliquiritin against corticosterone-induced neurotoxicity in PC12 cells.   Food Funct. 2017, 8(3): 1235-1244.(2016 IF 3.247)

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450

[12]

Wang Dong-Mei, Feng Bo, Fu Hui, Liu Ai-Lin,  Wang Lin, Du Guan-Hua, Wu Song*.   Design, Synthesis, and Biological Evaluation of a New Series of   Biphenyl/Bibenzyl Derivatives Functioning as Dual Inhibitors of   Acetylcholinesterase and Butyrylcholinesterase. Molecules. 2017, 22, 172. (2016   IF 2.861)

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460

[13]

王红蕊, 闫蓉, 高俐, 李正涛, 杨淬, 杜冠华. 黑种草子提取物调节血管内皮细胞功能及血管新生作用 [J]. 中国药理学通报, 2017, 33(11): 1611-1617.

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470

[14]

史静超,高晓霞,李浩,张斌,秦雪梅,杜冠华。中药复方治疗轻度认知障碍的研究进展。中药药理与临床,201736(10)1175-1179

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477

[15]

李佳琪,高丽*,周玉枝,秦雪梅,杜冠华*。衰老性学习记忆减退相关的脑内单胺类神经递质研究进展。药学学报,201752(11)1639-1646

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483

[16]

薛立英,高丽,秦雪梅,杜冠华,周玉枝*。药食同源中药抗衰老研究进展。食品科学,201738(15)302-309

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491

[17]

杜肖,路畅,贺晓丽*,杜冠华*。小续命汤有效成分组对脑缺血/再灌注大鼠恢复早期脑线粒体的保护作用研究。中国中药杂志,201742(11)2139-2145

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499

[18]

王珂欣,高丽*,周玉枝,张建琴,秦雪梅,杜冠华*。基于网络药理学的苦参碱抗肝癌作用及机制研究。药学学报,201752(6)888-896

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506

[19]

赵月蓉,侯碧玉,张莉,杜冠华*,管淑玉*。葛根素对实验性肝损伤的治疗作用研究进展。中国新药杂志,201726(9)1005-1010

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515

[20]

赵月蓉,侯碧玉,柳晨歌,王晓波,杜冠华,张莉*,管淑玉*。依帕司他对2型糖尿病大鼠肝损伤的作用。首都医科大学学报,201738(2)268-276

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521

[21]

周玉枝,闫明亮,高丽,秦雪梅*,杜冠华。衰老动物模型的研究及其在抗衰老药物活性筛选中的应用。中草药,201748(6)1061-1071

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530

[22]

赵凡凡,周玉枝*,高丽,秦雪梅,杜冠华*D-半乳糖致衰老大鼠模型的研究进展。药学学报,201752(3)347-354

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541

[23]

宫文霞,周玉枝*李肖,秦雪梅,杜冠华*。当归抗抑郁化学成分及药理作用研究进展。中草药,201647(21)3905-3911

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549

药物晶型与药物标准专题

[24]

Yang De-Zhi, Jiao Ling-Tai, Zhang Bao-Xi, Du Guan-hua, Lu Yang*.   Development of a new chlorogenic acid certified reference material for food   and drug analysis. J Pharm Biomed Anal. 2017, 140: 169-173.(2016 IF 3.255)

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556

[25]

Yang De-zhi, Gong Ning-bo, Zhang Li, Lu Yang*, Du Guan-hua.   Structural and computational study of 4 new solvatomorphs of Betulin: A   combined X-ray, hirshfeld surface, and thermal analysis. J Pharm Sci. 2017,106(3):   826-834.(2016 IF 2.415)

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561

[26]

邢逞,杨海光,张丽,杨世颖,杜冠华*,吕扬*。依达拉奉的多晶型研究。医药导报,201736(11)1225-1230

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570

[27]

焦凌泰,张丽,杨德智,杨世颖,杜冠华,吕扬*。尼莫地平两种晶型的拉曼光谱分析和溶出度实验。医药导报,201736(10)1175-1179

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576

[28]

张娜,赵赢,杨世颖,魏宁漪,吕扬*,杜冠华。不同来源普伐他汀钠原料药的晶型研究。药物分析杂志,201636(12)2139-2147

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581

[29]

杨雪薇,徐娟,宁丽峰,张丽,杨德智,王慧萍,杜冠华,吕凌,吕扬。醋酸乌利司他优势药用晶型研究。医药导报,201635(12)1340-1347

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590

药物代谢组学专题

[30]

Zhou Yu-Zhi*, Yan Ming-Liang, Gao Li, Zhang Jian-Qin, Qin   Xue-Mei*, Zhang Xiang, Du Guan-Hua. Metabonomics approach to   assessing the metabolism variation and gender gap of Drosophila melanogaster   in aging process. Exp Gerontol. 2017, 98:110-119.(2016 IF 3.340)

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598

[31]

Li Ai-Ping, Li Zhen-Yu*, Qu Ting-Li, Qin Xue-Mei*,   Du Guan-Hua. Nuclear magnetic resonance based metabolomic differentiation of   different Astragali Radix. Chin J Nat Med. 2017, 15(5):363-374.(2016 IF 1.667)

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608

[32]

Cui jia-Jia, Liu Yue-Tao*, Hu Ying-Huan, Tong Jia-Yu, Li Ai-Ping,   Qu Ting-Li, Qin Xue-Mei, Du Guan-Hua*. NMR-based metabonomics and   correlation analysis reveal potential biomarkers associated with chronic   atrophic gastritis. J Pharm Biomed Anal. 2017, 132: 77-86.(2016 IF 3.255)

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620

[33]

赵凡凡,周玉枝*,常艳芬,高丽,秦雪梅,杜冠华,张翔。基于1H-NMR代谢组学技术的D-半乳糖致衰老大鼠尿液代谢谱的动态变化。中国药理学与毒理学,201731(6)514-526

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630

[34]

赵凡凡,李肖,高丽,秦雪梅,杜冠华,周玉枝*。甘草水提物干预D-半乳糖致衰老大鼠的肝脏代谢组学研究。中草药,201748(17)3545-3553

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643

[35]

王桂臻,郝霞,刘磊,李震宇,秦雪梅,杜冠华,张翔,李科*。基于氯甲酸乙酯二次衍生化的GC-MS法同时测定生物样本中20种氨基酸。药学学报,201752(4)615-619

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652

[36]

王珂欣,高丽*,段丹丹,周玉枝,秦雪梅*,杜冠华。基于1H-NMR代谢组学的黄芩素干预D-半乳糖致衰老大鼠作用研究。中草药,201748(3)511-518

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657

[37]

何小燕,陈建丽,向欢,高耀,田俊生*,秦雪梅*,杜冠华。谷氨酸和皮质酮诱导的PC12抑郁症细胞模型差异性的1HNMR代谢组学研究。药学学报,201752(2)245-252

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665

其他

[38]

宋佳,高晓霞,田俊生,秦雪梅,杜冠华,周玉枝*。中药药对配伍机制的现代研究。中草药,201748(21)4367-4374

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673

[39]

王娟娟,秦雪梅*,高晓霞,张斌,王佩义,郝晋琪,杜冠华。杜仲化学成分、药理活性和质量控制现状研究进展。中草药,201748(15)3228-3237

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681

[40]

秦雪梅*,李爱平,刘月涛,张王宁,杜冠华。多效中药定向药效成分研究策略。中草药,201748(5)847-852

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691

[41]

王晓波,宋俊科,张雯,杨德智,王淑美,杜冠华*,孙悦*。丹酚酸A 含量的HPLC-ECD 检测方法。广东化工,201744(5)3-5

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697

[42]

赵晓喆,赵思俊,田俊生,高晓霞,张斌,王佩义,秦雪梅*,杜冠华。基于药效作用的龟龄集物质基础研究进展。中草药,201748(7)1424-1431

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700

[43]

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