王守宝

2016年12月15日

王守宝,男,汉族,1978年生,山东滕州人,副研究员,硕士生导师。

教育背景:

2006.09-2009.07北京协和医学院,药理学,博士

2002.09-2005.07成都中医药大学,药理学,硕士

1997.09-2002.07成都中医药大学,中药药理,学士

 工作经历:

2015.09 至今中国医学科学院&北京协和医学院,药物研究所,副研究员;

2014.01-2015.09 英国曼彻斯特大学 Faculty of Life Sciences,博士后;

2009.08-2015.08 中国医学科学院&北京协和医学院,药物研究所,助理研究员。

研究领域:

研究方向为心脑血管药理学与新药发现,主要兴趣为围绕线粒体结构和功能调控研究,从未折叠蛋白反应(Unfolded protein response, UPR)、线粒体相关内质网膜(Mitochondria-associated ER membrane, MAM)和线粒体动态(Mitochondrial Dynamics)调控等方向,探讨影响细胞功能的重要基因和蛋白质,寻找防治心脑血管疾病的新靶点和药物。

目前主持在研国家自然科学基金面上项目1项,重大新药创制科技重大专项十三五子课题1项,参加中国医学科学院医学与健康科技创新工程协同创新团队项目1项;已主持完成国家自然科学基金青年科学基金1项、中央级公益科研院所基本科研业务专项1项以及新疆维吾尔自治区重点实验室开放课题1项,参与多项国家重大新药创制科技重大专项十一五十二五课题、卫生公益性行业科研专项、北京市科技专项等。在国内外发表研究论文20余篇,申请国家发明专利1项,参与编译著作6部。兼任中国实验动物学会实验动物资源鉴定与评价工作委员会委员,中国医药质量管理协会转化医学分会委员,北京药学会应用与转化药学专业委员会委员等学术任职。

代表性论文:

1.          Shoubao Wang, Zhenzhong Wang, Qiru Fan, Jing Guo, Galli G, Guanhua Du, Xin Wang, Wei Xiao. Ginkgolide K protects the heart against ER stress injury by activating IRE1α/XBP1 pathway. Br J Pharmacol. 2016; 173(15):2402-18.

2.          Shoubao Wang, Pang Xiao-Bin, Gao Mei, Fang Lian-Hua, Du Guan-Hua. Pinocembrin protects rat against cerebral ischemic damage through soluble epoxide hydrolase and epoxyeicosatrienoic acids. Chinese Journal of Natural Medicines. 2013, 11(3):0207-13.

3.          Shoubao Wang, Wei-Ku Zhang, Xiao-Bin Pang, Li Li, Guo-Rong He, Xiu-Ying Yang, Lian-Hua Fang, Guan-Hua Du. EETs mediate cardioprotection of salvianolic acids through MAPK signaling pathway. Acta Pharmaceutica Sinica B. 2013, 3(1): 25–31.

4.          Shoubao Wang, Xiao-Bin Pang, Yan Zhao, Yue-Hua Wang, Li Zhang, Xiu-Ying Yang, Lian-Hua Fang, Guan-Hua Du. Protection of salvianolic acid A on rat brain from ischemic damage via soluble epoxide hydrolase inhibition. J Asian Nat Prod Res. 2012, 14(11): 1084-92.

5.          Shoubao Wang, Yang Xiu-Ying, Tian Shuo, Yang Hai-Guang, Du Guan-Hua. Effect of salvianolic acid A on vascular reactivity of streptozotocin-induced diabetic rats, Life Sci. 2010;85(13-14):499-504.

6.          Shoubao Wang, Tian Shuo, Yang Fan, Yang Hai-guang, Yang Xiu-ying, Du Guan-hua. Cardioprotective effect of salvianolic acid A on isoproterenol-induced myocardial infarction in rats. Eur J Pharmacol. 2009; 615(1-3):125-32.

7.          Rui ZhaoShoubao WangZhonglin HuangLi ZhangXiuying YangXiaoyu BaiDan ZhouZhizhen QinGuanhua Du. Lipopolysaccharide-induced serotonin transporter up-regulation involves PKG-I and p38MAPK activation partially through A3 adenosine receptor. Biosci Trends. 2015;9(6):367-76.

8.          Guo J,  Shoubao Wang, Yuan TY, Wu YJ, Yan Y, Li L, Xu XN, Gong LL, Qin HL, Fang LH, Du GH. Coptisine protects rat heart against myocardial ischemia/reperfusion injury by suppressing myocardial apoptosis and inflammation. Atherosclerosis. 2013;231(2):384-91.

9.          Yu Yan, Yu-Cai Chen, Yi-Huang Lin, Jing Guo, Zi-Ran Niu, Li Li, Shoubao Wang, Lian-Hua Fang, Guan-Hua Du. Brazilin isolated from the heartwood of Caesalpinia sappan L induces endothelium-dependent and -independent relaxation of rat aortic rings. Acta Pharmacol Sin. 2015;36(11):1318-26.

10.      Ran-Yao Yang, Gang Zhao, Dong-Mei Wang, Xiao-Cong Pang, Shoubao Wang, Jian-Song Fang, Chao Li, Ai-Lin Liu, Song Wu, Guan-Hua Du. DL0410 can reverse cognitive impairment, synaptic loss and reduce plaque load in APP/PS1 transgenic mice. Pharmacol Biochem Behav. 2015;139(Pt A):15-26.

11.      Xu XN, Niu ZR, Shoubao Wang, Chen YC, Gao L, Fang LH, Du GH. Effect and mechanism of total flavonoids of bugloss on rats with myocardial ischemia and reperfusion injury. Yao Xue Xue Bao. 2014, 49(6):875-881.

12.      Guo J, Li L, Wu YJ, Yan Y, Xu XN, Shoubao Wang, Yuan TY, Fang LH, Du GH. Inhibitory Effects of Brazilin on the Vascular Smooth Muscle Cell Proliferation and Migration Induced by PDGF-BB. Am J Chin Med. 2013;41(6):1283-96.

13.      Li L, Pang XB, Chen BN, Gao L, Wang L, Shoubao Wang, Wang SB, Liu DP, Du GH. Pinocembrin inhibits angiotensin II-induced vasoconstriction via suppression of the increase of [Ca2+]i and ERK1/2 activation through blocking AT1R in the rat aorta. Biochem Biophys Res Commun. 2013;435(1):69-75.

14.      Gong Li-Li, Fang Lian-Hua, Wang Su-Bo, Sun Jia-Lin, Qin Hai-Lin, Li Xiao-Xiu, Shoubao Wang, Du Guan-Hua. Coptisine exert cardioprotective effect through anti-oxidative and inhibition of RhoA/Rho kinase pathway on isoproterenol-induced myocardial infarction in rats. Atherosclerosis. 2012;222(1):50-8.

15.      Tian Shuo, Du Li-Da, Shoubao Wang, HE Guo-Rong, Yang Tao, Li Xiao-Xiu, Guo Jing, Du Guan-Hua. Pharmacokinetic Study of Baicalein and Its Major Metabolites after iv Administration in Dogs. Chinese Herbal Medicines. 2011; 03(3): 196-201.

16.      王守宝, 竺晓鸣, 高峰, 庞晓斌, 杜冠华.仓鼠糜酶2抑制剂高通量筛选模型的建立及其应用. 药学学报, 2012;47 (2): 168-173.

17.      王守宝, 郭晶, 俞晓明, 杜冠华.人源可溶性环氧化物水解酶抑制剂的高通量筛选. 药学学报, 2010 (11): 1367-72.

获得奖励

1.       2012年中国高校自然科学奖二等奖传统中药丹参的水溶性成分现代药理学研究(第4完成人,2012-080

2.       2011年中华医学科技奖三等奖天然产物的生物活性评价研究(第14完成人,201103036U0101