宋俊科

2016年11月21日

宋俊科,中国医学科学院药物研究所,筛选室,助理研究员2010/09-2015/06,中国医学科学院药物研究所,药理学,博士2006/09-2010/06,沈阳药科大学,药学院,基础药学基地班,学士2015/09-至今,中国医学科学院药物研究所,筛选室,助理研究员代表性研究成果和学术奖励情况Song JK, Zhang W, Sun JL, Zhang X, Xu XN, Zhang L, Du G

宋俊科,中国医学科学院药物研究所,筛选室,助理研究员

2010/09-2015/06,中国医学科学院药物研究所,药理学,博士

2006/09-2010/06,沈阳药科大学,药学院,基础药学基地班,学士

2015/09-至今,中国医学科学院药物研究所,筛选室,助理研究员

代表性研究成果和学术奖励情况

Song JK, Zhang W, Sun JL, Zhang X, Xu XN, Zhang L, Du GH*, Determination of salvianolic acid C in rat plasma using liquid chromatography-mass spectrometry and its application to pharmacokinetic study, Biomedical Chromatography, 2016, 30(3): 376-383.

Kong Hyesik#, Song JK#, Venkata Mahidhar Yenugonda, Zhang L, Tian S, Amrita K. Cheema, Kong YL, Du GH, Milton L. Brown, Preclinical Studies of the Potent and Selective Nicotinic α4β2 Receptor Ligand VMY-2-95*, Molecular Pharmaceutics, 2015, 12(2): 393-402.

Song JK, Zhang W, Sun JL, Xu XN, Zhang X, Zhang L, Feng ZY, Du GH*, Pharmacokinetic study of salvianolic acid D after oral and intravenous administration in rats, Acta Pharmaceutica Sinica B, 2015, 5 (3): 246-253.

宋俊科, 张雯, 张维库, 冯章英, 谢涛, 杜冠华*, 静脉注射丹酚酸A在恒河猴体内的药代动力学研究, 药学学报, 2015, 50 (9): 1142-1147.

Ma YZ, Li L, Song JK, Niu ZR, Liu HF, Zhou XS, Xie FS, Du GH*, A novel embolic middle cerebral artery occlusion model induced by thrombus formed in common carotid artery in rat, J Neurol Sci, 2015, 359: 275-279.

Xin WY, Tian S, Song JK, He GR, Mu X, Qin XM, Du GH. Research progress on pharmacological actions and mechanism of baicalein and baicalin [J], Current Opinion Complement Alternat Med, 2014, 1(2): e00010.

Zhou D, Zhou W, Song JK, Feng ZY, Yang RY, Wu S, Wang L, Liu AL, Du GH. DL0410, a novel dual cholinesterase inhibitor, protects mouse brains against Abeta-induced neuronal damage via the Akt/JNK signaling pathway [J], Acta Pharmacologica Sinica, 2016, 37(11): 1401-1412.

Ma Y, Li L, Niu Z, Song J, Lin Y, Zhang H, Du G. Effect of recombinant plasminogen activator timing on thrombolysis in a novel rat embolic stroke model [J], Pharmacological Research, 2016, 107: 291-299.

Sun L, Bai Y, Zhao R, Sun T, Cao R, Wang F, He G, Zhang W, Chen Y, Ye P, Du G. Oncological miR-182-3p, a Novel Smooth Muscle Cell Phenotype Modulator, Evidences From Model Rats and Patients [J], Arteriosclerosis, Thrombosis, and Vascular Biology, 2016, 36(7): 1386-1397.

Li C, Song X, Song J, Pang X, Wang Z, Zhao Y, Lian W, Liu A, Du G. Pharmacokinetic study of gallocatechin-7-gallate from Pithecellobium clypearia Benth. in rats [J], Acta Pharm Sin B, 2016, 6(1): 64-70.

Du G, Sun L, Zhao R, Du L, Song J, Zhang L, He G, Zhang Y, Zhang J. Polyphenols: Potential source of drugs for the treatment of ischaemic heart disease [J], Pharmacology and Therapeutics, 2016, 162: 23-34.

Sun L, Zhao R, Zhang L, Zhang W, He G, Yang S, Song J, Du G. Prevention of vascular smooth muscle cell proliferation and injury-induced neointimal hyperplasia by CREB-mediated p21 induction: An insight from a plant polyphenol [J], Biochemical Pharmacology, 2016, 103: 40-52.

Liu, R, Li JZ, Song JK, Zhou D, Huang C, Bai XY, Xie T, Zhang X, Li YJ, Wu CX, Zhang L, Li L, Zhang TT, Du GH*, Pinocembrin improves cognition and protects the neurovascular unit in Alzheimer related deficits, Neurobiol Aging 2014, 35(6): 1275-1285.

Liu, R, Li JZ, Song JK, Sun JL, Li YJ, Zhou SB, Zhang TT, Du GH*, Pinocembrin protects human brain microvascular endothelial cells against fibrillar amyloid-β (1-40) injury by suppressing the MAPK/NF-κB inflammatory pathways, BioMed research international, 2014: 470393.

Sun, JL, Zhang L, Song JK, Tian S, Huang C, Feng ZY, Du GH*, Pharmacokinetic study of salvianolic acid A in beagle dog after oral administration by a liquid chromatography-mass spectrometry method: a study on bioavailability and dose proportionality, J. Ethnopharmacol, 2013, 148(2): 617-623.

Tian, S, He GR, Song JK, Wang SB, Xin WY, Zhang D, Du GH*, Pharmacokinetic study of baicalein after oral administration in monkeys, Fitoterapia, 2012, 83(3): 532-540.

Yu Yang, Fan SM, Song JK, Shin-ichi Tashiro, Satoshi Onodera, Takashi Ikejima*, Hydroxyl Radical (•OH) Played a Pivotal Role in Oridonin-Induced Apoptosis and Autophagy in Human Epidermoid Carcinoma A431 Cells, Biological and Pharmaceutical Bulletin, 2012, 35(12): 2148-2159.

Huang, ZL, Liu R, Bai XY, Zhao G, Song JK, Wu S, Du GH*, Protective effects of the novel adenosine derivative WS0701 in a mouse model of posttraumatic stress disorder, Acta Pharmacol. Sin, 2014, 35(1): 24-32.

He YY, Yan Y, Zhang TT, Ma YZ, Zhang W, Wu P, Song JK, Wang S, Du G*, Lack of dose dependent kinetics of methyl salicylate-2-O-β-D-lactoside in rhesus monkeys after oral administration, Journal of Ethnopharmacology, 2015, 164: 293-300.

Liu, R, Zhang TT, Zhou D, Bai XY, Zhou WL, Huang C, Song JK, Du GH*, Quercetin protects against the Aβ25-35-induced amnesic injury: Involvement of inactivation of RAGE-mediated pathway and conservation of the NVU, Neuropharmacology, 2013, 67: 419-431.

冯章英, 宋俊科, 黄超, 刘艾林, 杜冠华*, 新型胆碱酯酶抑制剂 J39136 大鼠体内血药浓度测定方法的建立及组织分布研究, 中国新药杂志, 2014, 23(7): 775-780.

邢逞, 宋俊科, 张丽, 杨世颖, 史永强, 杜冠华*, 吕扬*, 利巴韦林的多晶型研究及药动学评价,中国药学杂志, 2013, 48(8): 621-628.

辛文妤, 宋俊科, 何国荣, 杜冠华*, 黄芩素和黄芩苷的药理作用及机制研究进展, 中国新药杂志, 2013, 22(6): 647-653.

孙加琳, 宋俊科, 邢程, 吕扬, 杜冠华*, 临床常用尼群地平片在大鼠体内药代动力学比较研究, 中国临床药理学与治疗学, 2012, 17(7): 755-760.

胡帆, 赵睿, 张丽, 宋俊科, 吕扬, 杜冠华*, 盐酸伐昔洛韦多晶型的溶解性质与药动学研究, 医药导报, 2012, 31(11): 1396-1400.

秦至臻,陈芊茜,宋俊科,吕扬,杜冠华*, 奥扎格雷两种晶型在大鼠体内的药代动力学研究, 药学学报, 2015, 50 (2): 218-221.

张雯,宋俊科,杜冠华*, 缺血再灌注损伤与细胞凋亡信号转导通路, 中国药学杂志, 2015, 50 (7): 565-569.

获得学术奖励

宋俊科(1/15),化学药物晶型关键技术体系的建立与应用,北京市,北京市科学技术进步奖一等奖,2014(杜冠华,吕扬,张丽,杨世颖,龚宁波,杨德智,何国荣,邢逞,杨庆云,谢平,孙加琳,胡帆,田硕,吴松,宋俊科)