王金华

2016年09月04日

这里是摘要描述

研究经历:


2016.4~至今  中国医学科学院药物研究所、北京协和医学院 研究员 博士生导师

 

2015.3-~至今  中国医学科学院药物研究所、北京协和医学院 研究员

 

2013.2~2015.3      Assistant professor, faculty. John Wayne Cancer Institute, Los Angeles, CA 90404 (美国)

 

2010.8~2013.1      Medical scientist, John Wayne Cancer Institute, Los Angeles, CA 90404. (美国)

 

2007.10~ 2010.7   Research Associate, Department of Molecular Oncology, John Wayne Cancer Institute. Los Angeles, CA 90404. (美国)

 

2006.7~ 2007.10   Research Associate, Department of Neuropathology, Case Western Reserve University, Cleveland, Ohio USA. (美国)

 

2004.6 ~ 2006.6    博士后,中国医学科学院药物研究所

 

1999.8 ~ 2004.6    硕、博连读,博士,北京大学医学部

 

1991.8-~ 1996     学士,   首都医科大学

 

 学术期刊编委及审稿人:Oncotarget,Pharmaceutical Biology,Molecular medicine report,Journal of Breast Cancer,Cancer Investigation, Asian Life Science,药学学报,中国药理学通报等杂志编委和审稿人。

 

发表SCI论文:


1. Jinhua Wang*, Ying Qu*, Partha S. Ray et al. Thioredoxin-like 2 regulates human cancer cell growth and metastasis via redox homeostasis and NF-κB signaling. Journal of Clinical Investigation. 2011;121(1):212-225. (The article was elected as highlighted article) (IF:14.689)

 

2. Jinhua Wang*,Partha S. Ray*, Ying Qu* et al. FOXC1 is a prognostic biomarker and is functionally necessary for maintenance of aggressive cellular features in basal-like breast cancer. Cancer Research, 2010; 70(10):1-7.(The pictures in the article were chosen as the cover of magazine) (IF:8.576)

 

3. Jinhua Wang, I Kuiatse , AJ Casa ,AV Lee ,X Cui. JNK, essential for anticancer   therapy-induced apoptosis promotes cancer breast progession. Cancer Research, 2009; 69( suppl.):(2).January 15,2009 (IF:8.576)

 

4. Jinhua Wang, Ying Qu, Xiaojiang, et Cui et al. FOXC1 orchestrates basal-like breast cancer cell functions by regulating NF-KB signaling (Oncogene, 2012 Nov 8;31(45):4798-802)     (IF:7.18)

 

5. Jinhua Wang, Sharon Hunag, Ling Takeshima et al. Acquire resistance to braf-inhibitor by increasing EGFR expression.  Journal of Investigative Dermatology . 2015; 135:532–541. (IF:7.216)

 

6. Jinhua Wang, Wei hua  Sharon Huang et al. RASSF8 Regulates Progression of Cutaneous Melanoma through Nuclear  Factor-κb. (Oncotarget,  2015:6:30165-30177)  (IF:6.63 )

 

7. Jinhua Wang, Kelly K. Chong, Yoshitaka Nakamura et al. B7-H3 Associated with Tumor Progression and Epigenetic Regulatory Activity in Cutaneous Melanoma. Journal of Investigative Dermatology. 2013; 133(8):2050-8. ( IF:6.19)

 

8. Jinhua Wang, Isere Kuiatse, Adrian V. Lee et al. Sustained JNK Activity Promotes Epithelial-Mesenchymal Transition, Invasion, and Survival of Breast Cancer Cells by Regulating ERK Activation. (Molecular Cancer Research, 2010; 8(2):266-277). (The article was elected as highlighted article) (IF:4.937)

 

9. Jinhua Wang*, Ying Qu*, Bingya Liu, Armando Giuliano, James Barsoum, and Xiaojiang  Cui. Elesclomol, counteracted by Akt survival signaling, enhances the apoptotic effect of  chemotherapy drugs in breast cancer cells.   (Breast Cancer Research Treatment, 2010;121(2):311-21. (IF:4.467)

 

10. Jinhua Wang, Weibo Ka, DaGong Sun, Weijuan Yao, ZongYao Wen , and Shu  Chien.Synergistic effect of cytokines EPO, IL-3 and SCF on the proliferation, differentiation and apoptosis of erythroid progenitor cells. Clinical Hemorheology and microcirculation. Clinical Hemorheology and micro circulation. 2007; 37(4): 291-9. (IF:3.398)

 

11. Jinhua Wang, Weibo Ka, Zhiyu Tang et al. Rheological studies on precursor cells at different stage in mice. Clinical Hemorheology and microcirculation. 2003, 29:63-69. (IF:3.398)

 

12. Jinhua Wang, Weibo Ka, DaGongSun, Weijuan Yao, ZongYao Wen, Shu Chien. Biochemical and biophysical studies on the precursor cells of mouse erythrocytes at different stages. Cell Biochemistry and Biophysics .2006, 45:147-156. (the article was elected as highlighted article) (IF:2.7)

 

13. Jin-Hua Wang*,Qing-Shan Liu*, Jian Cui, Zhi-Hong Yang, Guan-Hua Du. A novel acute anemia model for pharmacological research in mice by compelled acute exercise. Acta Pharmacologica Sinica (2009) 30: 1643-1647. (IF:2.521)

 

14. Jinhua Wang, Weibo Ka, Dagong Sun et al Biophysical and biorheology studies on the precursor cells at different stages. Science in China (Series. C). 2002, 45: 421-428. (IF:1.2)

 

15. P.S Ray , Jinhua Wang, Ying Qu,  et al. Role of FOXC1 in regulation of   basal-like/triple-negative breast cancer. Journal of Clinical Oncology. 2009; 27: 562S (No 15S, Part I of II). (IF:17.255) 

 

16. Jensen TW, Ray T, Wang Jinhua, Li X et al. Diagnosis of Basal-Like Breast Cancer Using a FOXC1-Based Assay. J Natl Cancer Inst. 2015 Jun 3;107(8). (IF:13.584) 

 

17. Min Feng, Yi Bao, Zhimei Li, Juntao Li, Min Gong, Jinhua Wang, Dave S.B. Hoon, and Qiang Yu. RASAL2 activates RAC1 to promote triple-negative breast cancer progression. J Clin Invest. 2014;124(12):5291–5304. (IF: 13.261)

 

18. Shuet Theng Lee, min feng …. Jinhua Wang et al. Protein Tyrosine Phosphatase UBASH3B is Overexpressed in Triple-Negative Breast Cancer and Promotes Invasion and Metastasis. Proc Natl Acad Sci U S A  2013 Jul 2;110(27):11121-6. (IF:9.598)

 

19. Marzese DM, Scolyer RA,….Jinhua Wang, Kawas NP, Donovan NC, Hata K, Wilmott JS, Murali R, Buckland ME, Shivalingham B, Thompson JF, Morton DL, Kelly DF and Hoon DSB. Epigenome-wide DNA Methylation Landscape of Melanoma Progression to Brain Metastasis Reveals Aberrations on Homeobox D Cluster Associated with Prognosis. Human Molecular Genetics, 2013; 23(1): 226-38.  (IF:7.541)

 

20. Katsuya Ohta, Hiromitsu Hoshino, Jinhua Wang, et al.MicroRNA-93 activates c-Met/PI3K/Akt pathway activity in hepatocellular carcinoma by directly inhibiting PTEN and CDKN1A. Oncotarget. 2015:6(5):3211-24. (IF: 6.63)

 

21. Sanjay P. Bagaria*, Partha S. Ray*, Jinhua Wang, Alice Chung, Jaime Shamonki,  Xiaojiang Cui, Armando E. Giulian.  Prognostic value of basal phenotype in  HER2-overexpressing breast cancer(Annual of surgical oncology, 2012; 19(3): 935-40. (IF:4.308)

 

22. Partha S Ray*, Sanjay P Bagaria*, Jinhua Wang, Jaime M Shamonki. Basal-like breast cancer defined by FOXC1 expression offers superior prognostic. value: a retrospective immunohistochemical study. (Annual of surgical oncology,  2011 18:3839–3847 (IF:4.308)

 

23. Dagong Sun, Jinhua Wang, Weijuan Yao. Tumorigenesis of murine erythroleukeia cell  line transfected with exogenous p53 gene. Clinical Hemorheology and microcirculation  Clinical Hemorheology and micro circulation. 2004, 30:117-126. (IF:3.398)

 

24. Fangyun Sun* ,Xiuping Chen*, Jinhua Wang, et al. Arjunic acid, a strong free radical scavenger from Terminalia arjuna. Am J Chin Med. 2008;36(1):197-207291-9 (IF:1.969)

 

25. Chen X, Sun F, Ma L, Jinhua Wang, Qin H, Guanhua Du . In vitro evaluation on the antioxidant capacity of triethylchebulate, an aglycone from Terminalia chebula Retz fruit. Indian Pharmacol, 2011 May;43(3):320-3. 291-9 (IF:0.667) 

 

26. Marzese DM, Liu M, Huynh JL, …., , Wang J, Morton DL, Barkhoudarian G, Kelly DF,Hoon DS Brain metastasis is predetermined in early stage of  cutaneous melanoma by CD44v6 expression through epigenetic regulation of the spliceosome. Pigment Cell Melanoma Res. 2015 Jan;28(1):82-93 (IF:4.619)  

 

27.Vaspin 和肥胖及 2 型糖尿病

刘师伟 王金华 杨静

中华内分泌代谢杂志2011(27).No.5

 

28.生长发育过程中血细胞流变学特性的研究进展( 综述 )

王金华 蒋玉辉 唐志宇 曾柱

中国生物医学工程学报2006(25).No.2

 

29.基于FP法的EPOR 配体高通量筛选模型

王金华 韩光亮 张天泰 杜冠华

中国药理学通报2006 Jan;22(1):114~7

 

30.诃子的药理作用研究进展

王金华 孙芳云  杜冠华

中国民族医药杂志1006-6810(2006)06-0045-03

 

31.促红细胞生成素的信号传导及其生物学作用的研究进展

王金华 杜冠华

医学分子生物学杂质2005,2(6):440-443

 

32.用激光衍射法测量网织红细胞膜剪切弹性膜量(E)及表面粘度(μm)

王金华  喀蔚波  孙大公等

中国生物医学工程学报 2005年24卷04期 468-471.

 

33.不同发育阶段红系造血细胞的流变特性的研究

王金华  喀蔚波  孙大公等

中国生物医学工程学报 2004(23).No.1

 

34.小鼠网织红细胞微观流变学特性的研究

王金华  喀蔚波  唐志宇等

生物物理学报2004年第3期 173-177.

 

35.CFU及其分化细胞的生物物理特性

王金华  岳黎  唐军民等

生物物理学报 2003(19)367-371

 

36.红细胞和内皮细胞的粘附研究进展

王金华  姚伟娟  喀蔚波 

北京生物医学工程 2001(20)302-305

 

37.病理条件下白细胞与内皮细胞的粘附

王金华 喀蔚波 孙大公 文宗曜

中国血液流变学杂质2000;10(4)

 

38.大花红景天的抗氧化性溶血作用研究

孙芳云 王金华 张斌 梁智 秦海林 杜冠华

中药药理与临床2006;22(3、4)

 

39.新型CKLF1对家兔红系造血祖细胞增殖分化的影响

岳黎敏 唐军民  苏安英 唐岩  王金华  汪涛  文宗曜

解剖学报2004(35)04-382

 

国际专利: 


Patent 1: METHODS FOR DIAGNOSIS, PROGNOSIS AND TREATMENT OF PRIMARY AND METASTATIC BASAL-LIKE BREAST CANCER AND OTHER CANCER TYPES  (Patent  No. US 9074253 B2    授权日: 2015.7.7).

Patent 2: DIAGNOSIS OF PRIMARY AND METASTATIC BASAL-LIKE BREAST CANCER AND OTHER CANCER TYPES   (Patent  No. EP 2486149 B1    授权日: 2015.6.17).

 

承担科研项目:


1.2005 Thirty-Seventh Postdoctoral fund(NO.2005037103)

 

2. 2014 Award from Associates for Breast and Prostate Cancer Research

 

3. 2014 Award from Margie and Robert E.Peterson breast cancer program

 

4. 2015 中国医学科学院药物所引进人才科研基金

 

5.重点运行基金

 

6.2016 国家自然科学基金

 

7. “重大新药创制”国家科技重大专项项目,2013ZX09402203、现代中药创新集群与数字制药技术平台、2013/01-2016/12

 

参编专著:


1.  Pharmology of Danshan.  ISBN:978-7-117-09935-6/R.9936.  2008,Page:242-248


2.  Animal models for human common diseases. ISBN: 978-7-81116-231-8.   2007,Page:88-85